ß-endorphin induces general anaesthesia by an interaction with opiate receptors
نویسندگان
چکیده
منابع مشابه
Pain Relief with Wet Cupping Therapy in Rats is Mediated by Heat Shock Protein 70 and ß-Endorphin
Background: Wet cupping therapy is a complementary therapy in pain management. The mechanism of this therapy, however, needs further elucidation. Cells injured by wet cupping therapy seem to stimulate the expression of heat shock protein 70 (HSP70). Its benefit in pain reduction could be mediated by the expression of ß-endorphin. This study aimed at determining the correlation between HSP70 and...
متن کاملInteraction of ligands with the opiate receptors of brain membranes: regulation by ions and nucleotides.
This study shows that nucleotides, as well as ions, regulate the opiate receptors of brain. GMP-P(NH)P and Na(+) reduce the amount of steady-state specific [(3)H]dihydromorphine binding and increase the rate of dissociation of the ligand from the opiate receptor. In contrast, Mn(2+) decreases the rate of ligand dissociation and antagonizes the ability of Na(+) to increase dissociation. The effe...
متن کاملMultiple Opiate Receptors
The use of very low concentrations of 1251-[D-Ala2,DLeu5]enkephalin, [3H]naloxone, and [3H]dihydromorphine under similar conditions enables the measurement of different opiate binding sites in a rat brain membrane preparation. In the absence of sodium ions, one such site binds enkephalins and their D-Ala2-substituted analogs with higher affinity than morphine and naloxone (enkephalin receptor),...
متن کاملBinding of 3H-beta-endorphin to rat brain membranes: characterization of opiate properties and interaction with ACTH.
The binding of tritiated beta-endorphin (3H-beta-EP) to brain homogenates is described. This has been difficult to achieve due to the lack of availability of 3H-beta-EP and to technical difficulties associated with high non-specific binding of beta-EP. We now report that 3H-beta-EP binding is saturable, stereospecific, has high affinity and is inhibited by sodium. Its dissociation rate is ten-f...
متن کاملMyocardial Opiate Receptors
The effect of morphine and niet-enkephaline on the isometric contraction of rabbit papillary muscles was studied. The tested compounds produced a dose-dependent, stereospecific and naloxon-reversible negative inotropic effect indicating the existence of opiate receptors in cardiac muscle. A pretreatment of papillary muscles with the /3-blocking agent atenolol attenuated the negative inotropic a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Anaesthetists’ Society Journal
سال: 1980
ISSN: 0008-2856,1496-8975
DOI: 10.1007/bf03006880